The Youth and Vocational Pastoral Center of the Sacro Convento organizes initiatives for young people in order to help them in their journey of life and discernment, taking into account the various ages and accompanying life stages. The Center also supports priests and other ministers of youth groups, who come to Assisi on pilgrimage, seeking a spiritual journey in the footsteps of Francis.

Among the events held every year in the Basilica of St. Francis are:
- Giovani verso Assisi (Youth to Assisi) national (Italy) annual meeting for 18-28 year olds (All Saints' Day)
- Settimane di spiritualità per adolescenti (Week of Spirituality for Adolescents) [during the summer months]
- Weekend e settimane 'vocazionale' (Weekend and Week-long vocational discernment)

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